Toxicogenomics

Toxicogenomics: Principles and Applications fills the need for a single, thorough text on the key breakthrough technologies in genomics, proteomics, metabolomics, and bioinformatics, and their applications to toxicology research. The first section following a general introduction is on genomics and toxicogenomics, and qPCR. With the sequencing of human and other genomes completed, the new field of toxicogenomics is now emerging into the realm of practice. This field brings together many different disciplines to incorporate current genomics knowledge into traditional toxicology. By finding more precise ways to measure the response of living systems and environments to chemical exposures, toxicogenomics promises to greatly alter and improve the drug development process, to name just one area of application. Toxicogenomics: Principles and Applications provides a unified, thorough text on key breakthrough technologies in genomics, proteomics, metabonomics, and bioinformatics, as well as their applications to toxicology research. Coverage includes: A general introduction to toxicology for nonspecialists Microarray/high-density gene expression profiling Quantitative RNA measurement Analysis of metabolites (metabonomics) Statistics and databases for toxicogenomics Functional genomics models Protein analysis and profiling Throughout Toxicogenomics, the emphasis remains on information practitioners can put to use immediately. Numerous illustrations support the text, and a helpful summary lists key software and Internet tools, as well as additional resources. Written for specialists and nonspecialists alike, Toxicogenomics gives a wide range of researchers access to the unique combination of disciplines that characterize this exciting new field. Toxicogenomics: Principles and Applications fills the need for a single, thorough text on the key breakthrough technologies in genomics, proteomics, metabolomics, and bioinformatics, and their applications to toxicology research. The first section following a general introduction is on genomics and toxicogenomics, and qPCR. The next sections are toxicoproteomics and metabolomics. The final section covers bioinformatics aspects, from databases to data integration strategies. A practical resource for specialists and non-specialists alike, this book includes numerous illustrations that support the textual explanations. It offers practical guidance to investigators wishing to pursue this line of research, and lists key relevant software and Internet resources.