Synthetic studies on Glycosyl hydrazino carbothioamides

In view of applications of N-glycosylated compounds in medicinal chemistry and in many other ways, herein the synthesis of novel glycosylhydrazino carbothioamides is reported. New N-glycosyl hydrazino carbothioamides were synthesized by the condensation of per-O-acetyl glycosyl isothiocyanate with different aromatic hydrazides. The presented protocol consists of a simple isolation method with moderate to good yields under mild conditions. Confirmation of novel prepared compounds was done using IR, 1H NMR and Mass spectral studies. Specific rotation of the title compounds was determined using a polarimetric study. All the newly synthesized N-glycosyl hydrazino carbothioamides exhibit moderate to good antimicrobial activities. against a variety of pathogen.