Sepsis and Organ Dysfunction

Even if in the last years more information on sepsis and new treatments has become available, mortality rate is however high. Another major problem is the consequent organ failure, which grows in a sequential way and in relation with the lesion gravity and the functional reserves of the patient. This volume presents the most recent results of research in the study of sepsis and the new treatments that have become available, mortality rate however still being high. It focuses on the complexity of the several biohumoral factors involved in this process and the consequent organ failure, which grows in a sequential way and in relation with the lesion gravity and the functional reserves of the patient.

Sepsis is a syndrome or sometimes it is a clinical condition evoked by uncontrolled endotoxin-reactions. These pathophysiological alterations can disturb the organism's homeostasis leading ultimately to a condition of severe organ dysfunction which in itself means a bad prognosis for patient survival. In the last decades researchers and clinicians have been involved in process directed to a better understanding of the basic mechanisms of sepsis and MODS. The best goal will be the achievement of preventive measures and optimization of management in patients suffering severe infections and critical conditions. This objective represents a true challenge at the dawn of the XXI century.