Second Generation of Calcium Antagonists

Providing an account of recent developments in the field, this study emphasizes the rationale for the development of second-generation calcium antagonists and the advantages associated with their use. It also explains the basis of tissue selectivity exhibited by some of the newer drugs. This text provides an up-to-date account of recent developments in the field of calcium antagonism. Emphasis has been placed in particular on the rationale for the development of second-generation calcium antagonists and the advantages associated with their use. The book shows why the second generation of antagonists offer specific advantages over the first generation and explains the basis of the tissue selectivity exhibited by some of these newer drugs. Recent advances are explained which unravel the molecular architecture of the calcium channel and its associated calcium antagonist binding sites. Specific second-generation calcium antagonists are described as examples of this new direction of development in the overall field of calcium antagonism.