Next Generation Sequencing in Cancer Research

It aims to systematically introduce the concept of NGS, a variety of NGS platforms and their practical implications in cancer biology.This unique and comprehensive text will integrate the unprecedented NGS technology into various cancer research projects as opposed to most books which offer a detailed description of the technology. Next Generation Sequencing (NGS) technology has placed importantmilestones in the life science and changed the directionin biomedical science inclucing cancer. Scientists around theworld are attempting to find the root cause of cancer and theyare looking for more direct and effective means to cure cancer.This journey to conquer cancer is more optimistic now withthe unfolding of the cancer genome. This book focuses on theapplication of various NGS in the frontier cancer genome research.The 18 chapters in this volume have been written byscientists with many outstanding contributions in their areaand the join effort has created comprehensive insightful viewon (1) Overview of next generation sequencing technology incancer genome research (2) Genome regulation and targetedsequencing in cancer (3) RNA transcriptome (coding andnon-coding) in cancer genome (4)The challenges of computationalbiology for cancer genome study.This book is a state-of-the-art reference to all scientific researchersand onologists who are interested in the understandingof the cancer initiatome at whole genome scale and to thoseare keen to translate the ‘base pairs to bedside’ for better managementof cancer patients in the era of personalized medicine. ​​​​This volume provides an interdisciplinary perspective of applying Next Generation Sequencing (NGS) technology to cancer research. It aims to systematically introduce the concept of NGS, a variety of NGS platforms and their practical implications in cancer biology.This unique and comprehensive text will integrate the unprecedented NGS technology into various cancer research projects as opposed to most books which offer a detailed description of the technology. This volume will present true experimental results with concrete data processing pipelines, discuss the bottleneck of each platform for real project in cancer research. In additional, single cancer cell sequencing as the proof of concept will be introduced in this book, along with cutting-edge information provided will help the intended audience to develop a comprehensive understanding of the NGS technology and practical whole genome sequencing data analysis and rapidly translate into their own research, specifically in the field of cancer biology.

This volume provides an interdisciplinary perspective of applying Next Generation Sequencing (NGS) technology to cancer research. It aims to systematically introduce the concept of NGS, a variety of NGS platforms and their practical implications in cancer biology.This unique and comprehensive text will integrate the unprecedented NGS technology into various cancer research projects as opposed to most books which offer a detailed description of the technology. This volume will present true experimental results with concrete data processing pipelines, discuss the bottleneck of each platform for real project in cancer research. In additional, single cancer cell sequencing as the proof of concept will be introduced in this book, along with cutting-edge information provided will help the intended audience to develop a comprehensive understanding of the NGS technology and practical whole genome sequencing data analysis and rapidly translate into their own research, specifically in the field of cancer biology.