Hyperhomocysteinemia (HHcys) in rheumatoid arthritis (RA) is associated with various causes, such as inflammation and folate or vitamin B12 deficiencies. The objectives of this study were to determine the prevalence of HHcys and to investigate the relationship between HHcys, systemic inflammation, and the clinical and biological characteristics of RA. HHcys was associated with inflammatory activity in RA and varied with folate and vitamin B12 levels. Controlling HHcys could contribute to better management of the disease.
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