Biological Reaction Engineering

Bol

This book explains and provides engineers and scientists with the information they need to analyze the behavior of complex biological reactors using a unique combination of mathematical equations and the powerful dynamic simulation language, Berkeley Madonna. This book explains modeling and simulation of the dynamics of biological processes in a readily comprehensible manner, using the unique combination of simplified fundamental theory and direct hands-on computer simulation. Biological systems modeled range from single enzymes to metabolic and multi-organism systems. The models for the kinetics are combined with the models of the reactors, which often include flow configuration and mass transfer aspects. In these many examples, bioreactor control and the optimization of their operation is also of interest. Simulation examples start from most simple ones reaching into recent research examples. The mathematics is kept to a minimum, and yet the numerous examples illustrate almost every aspect of biological engineering science, with each one described in detail, including the model equations. The example programs are written in the modern, user-friendly simulation language Berkeley Madonna. Madonna solves models comprising many ordinary differential equations using very simple programming. Data may be included for curve fitting, and sensitivity or multiple runs may be performed. The results can be viewed simultaneously on multiple-graph windows or by using overlays. The examples can be varied to fit any real situation, and the suggested exercises provide practical guidance. The extensive teaching and research experience of the authors is reflected in this well-balanced presentation, which is suitable for every biochemist, biologist, bioengineer and chemical engineer interested in modeling and simulation. The applied software Berkeley Madonna for Mac and PC is available from the Berkeley Madonna website: www.berkeleymadonna.com By choosing Supplementary Material from this WILEY-VCH webpage, a Zip file can be downloaded. This contains all simulation example programs for the book, solutions of modeling exercises and a short description to using Berkeley Madonna. Buyers of the book can buy the full Berkeley Madonna software at a reduced cost, as described in the appendix of the book.

Bol Partner

This book is the admirable result of ten years' experience in organizing and teaching courses in biological reaction engineering. It gives engineers and scientists the information they need to analyze the behavior of complex biological reactors using mathematical equations and a dynamic simulation computer language. Part I treats the fundamentals of modelling (mass balance equations, involving reaction kinetics and mass-transfer rates), making them readily understandable to those new in the field.Part II gives 45 example problems, complete with models and programs. This book is the first of its kind to include a diskette with a commercial simulation language. The diskette can be run on any DOS personal computer. Users will appreciate how the simulation runs can be interrupted for interactive parameter changes and instructive plotting.