Biochemical Basis of Cell and Matrix Interaction: Molecular Architecture, Regulatory Mechanisms, Disease Pathogenesis

This book presents an integrated overview of the components of extracellular matrix, cell - extracellular matrix interaction, and cell-cell interactions. Emphasizing on the molecular composition, structural organization, and functional significance in tissue integrity and cellular communication, and explores diverse cell-matrix interaction systems, including integrin-mediated interactions, focal adhesions, hemidesmosomes, syndecan-mediated interactions, discoidin domain receptors, selectin-glycoprotein interactions, and hyaluronan-CD44 interactions, highlighting their involvement in cell adhesion, migration, differentiation, immune responses, and disease processes. Overall, the text provides a concise yet comprehensive framework for understanding how molecular interactions between cells and their microenvironment regulate normal physiology and contribute to pathological conditions.